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KMID : 1007520150240010301
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Food Science and Biotechnology
2015 Volume.24 No. 1 p.301 ~ p.306
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In vitro Efficacy Evaluation for Prevention of Diabetes and Diabetic Complications Using Aster sphathulifolius
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Yin Xing-Fu
Jeon Young-Eun
Chung Hee-Chul
Choung Se-Young
Shim Jae-Hoon
Kang Il-Jun
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Abstract
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The efficacy of Aster sphathulifolius (AS) for evaluation of preventive potencies against diabetes and diabetic complications was analyzed by assessment of inhibitory effects against advanced glycation end-products (AGEs) formation, rat lens aldose reductase (RLAR), α- glucosidase activity, and scavenging effects against DPPH. The 50% ethanol extract showed the highest DPPH radical scavenging activity (82.38%) at a concentration of 100 μg/ mL, exhibited the most potent AGEs formation inhibitory effect (93.88%) at a concentration of 200 μg/mL, showed the most potent RLAR inhibitory effect (86.44%) at a concentration of 11.11 μg/mL. The 95% ethanol extract showed a potent α-glucosidase inhibitory activity (19.16%) at a concentration of 1 mg/mL. The 50% ethanol extract value was 16.79%. The 50% ethanol extract exhibited the most potent antioxidant and preventive actions against diabetes and diabetic complications and can, thus, be a source of valuable compounds for prevention of diabetes and diabetic complications.
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KEYWORD
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ster sphathulifolius, DPPH, advanced glycation end-products, rat lens aldose reductase, α-glucosidase
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